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Citation

Thesis Title
Synthetic targets as mechanistic probes for the key biosynthetic enzyme, dehydroquinate synthase

Read article at Massey Research Online:

More than thirty years have elapsed since the last truly novel antibacterial drug was released onto the prescription market. Given the rise of super-bugs there is an urgent need to discover new antimicrobial agents. One approach is to look at ways of disrupting bacterial enzymatic pathways; thereby killing bacteria. To this end, Mr Negron studied a specific enzyme within bacteria to understand how the enzyme carries out its reaction. His research has shed light on the mechanism of a vital bacterial enzyme and provides a starting point for the design of future antimicrobial agents.

Supervisors
Associate Professor Emily Parker
Professor Geoff Jameson