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Prof Vyacheslav Filichev staff profile picture

Contact details +6469517659

Prof Vyacheslav Filichev MSc, PhD

Professor in Chemistry

Doctoral Supervisor
School of Food Technology and Natural Sciences

Scientific curiosity and passion have driven my academic career and enabled me to become an expert in the physico-chemical analysis of many different DNA secondary structures, such as duplexes, triplexes and G-quadruplexes. My work on highly-specific flexible intercalating units embedded into DNA led to the discovery of a novel class of molecules (twisted intercalating nucleic acid, TINA) that enables formation of stable DNA triplexes or G-quadruplexes. This work has laid the foundation for the 1st Platform.

My interest in development of novel tools for chemists inspired by Nature is behind the research on DNA-based chiral catalysis (Platform 2), while my research activity in the field of assembly of organic chromophores on the DNA scaffold is behind the project on DNA-based low-energy photon upconverters (Platform 3).

My knowledge in the functionalisation and manipulation of DNA on the pre- and post-synthetic level is pivotal for the success of these projects.

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Professional

Qualifications

  • Master of Science - St Petersburg State Technological Institute (1999)
  • Doctor of Philosophy - St Petersburg State Technological Institute (2001)

Certifications and Registrations

  • Licence, Supervisor, 羞羞视频

Research Expertise

Research Interests

Development of novel drugs and diagnostic tools using DNA and RNA.

Area of Expertise

Field of research codes
Biochemistry and Cell Biology (060100): Biological Sciences (060000):
Chemical Science (030000): Medicinal and Biomolecular Chemistry (030400): Organic Chemistry (030500):
Structural Biology (incl. Macromolecular Modelling) (060112)

Research Projects

Current Projects

Project Title: Inhibiting evolution of cancer cell diversity and therapeutic resistance through inhibition of key mutator of genomic DNA in cancer cells (Maurice Wilkins Centre of Research Excellence)

Date Range: 2023 - 2024

Funding Body: University of Auckland

Project Team:

Project Title: Structural basis of viral wars: Innate immune system attack on viral genomes and the counterattack by viruses.

From the dawn of humanity, war has raged between viruses and human immunity. A key first line of defence is the APOBEC3 family of enzymes, which target specific DNA-sequence motifs to mutate single-stranded viral DNA preventing replication and diseases, such as HIV-AIDS, herpes, hepatitis and more. In turn, many viruses contain genes that trick the human host into producing proteins that disable APOBEC3. HIV-1 produces protein Vif that hijacks a protein-recycling assembly to bind APOBEC3G and target it for destruction. We will determine the structural basis of this war, to address three questions: (1) How does the two-domain APOBEC3G synergistically couple these domains to target efficiently triple cytosine (-CCC-) motifs of HIV-1 and then mutate a cytosine to uracil. (2) How does viral Vif interact with human APOBEC3G to counteract destruction of its (viral) genome. (3) How does Vif interact with APOBEC3G and single-stranded DNA to permit a low level of APOBEC3G activity that HIV-1 uses to evolve fitness? Structure-elucidation of APOBEC3G-DNA, APOBEC3G-Vif and APOBEC3G-Vif-DNA complexes will use small-angle X-ray scattering techniques to provide low-resolution structures and to determine the optimum conditions for selected high-resolution structures using advanced cryogenic-electron-microscopy techniques. Our results form the basis for new anti-viral strategies.
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Date Range: 2023 - 2026

Funding Bodies: Royal Society of New Zealand; Marsden Fund - Full

Project Team:

Project Title: Stopping breast cancer evolution: evaluation of APOBEC3 inhibitors in live cells

Date Range: 2021 - 2023

Funding Body: Health Research Council of New Zealand

Project Team:

Research Outputs

Journal

Chilton, B., Roach, RJ., Edwards, PJB., Jameson, GB., Hale, TK., & Filichev, VV. (2024). Inverted strand polarity yields thermodynamically stable G-quadruplexes and prevents duplex formation within extended DNA. Chemical Science. 15(37), 15417-15431
[Journal article]Authored by: Edwards, P., Filichev, V., Hale, T., Jameson, G.
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Kvach, MV., Harjes, S., Kurup, HM., Jameson, GB., Harjes, E., & Filichev, VV. (2024). Synthesis of 1,4-azaphosphinine nucleosides and evaluation as inhibitors of human cytidine deaminase and APOBEC3A. Beilstein Journal of Organic Chemistry. 20, 1088-1098
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Garavís, M., Edwards, PJB., Serrano-Chacón, I., Doluca, O., Filichev, VV., & González, C. (2024). Understanding int er calativ e modulation of G-ric h sequence folding: solution structure of a TINA-conjugated antiparallel DNA triplex. Nucleic Acids Research. 52(5), 2686-2697
[Journal article]Authored by: Edwards, P., Filichev, V.
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Harjes, S., Kurup, HM., Rieffer, AE., Bayarjargal, M., Filitcheva, J., Su, Y., . . . Jameson, GB. (2023). Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nature Communications. 14(1)
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G., Kurup, H.
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Kurup, HM., Kvach, MV., Harjes, S., Jameson, GB., Harjes, E., & Filichev, VV. (2023). Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A. Organic and Biomolecular Chemistry. 21(24), 5117-5128
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Harjes, S., Kurup, HM., Rieffer, AE., Bayarjargal, M., Filichetva, J., Su, Y., . . . Jameson, GB. (2023). Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nature Communications. 14, Retrieved from https://www.nature.com/articles/s41467-023-42174-w
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G., Kurup, H.
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Harjes, S., Kurup, HM., Rieffer, AE., Bayaijargal, M., Filitcheva, J., Su, Y., . . . Jameson, GB. (2023). Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A.. Nature Communications. 14, Retrieved from https://www.nature.com/articles/s41467-023-42174-w
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G., Kurup, H.
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Kurup, HM., Kvach, MV., Harjes, S., Barzak, FM., Jameson, GB., Harjes, E., . . . Filichev, VV. (2022). Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A. Biochemistry. 61(22), 2568-2578
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Barzak, FM., Ryan, TM., Mohammadzadeh, N., Harjes, S., Kvach, MV., Kurup, HM., . . . Jameson, GB. (2022). Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity. Viruses. 14(9)
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Su, Y., Raguraman, P., Veedu, RN., & Filichev, VV. (2022). Phosphorothioate modification improves exon-skipping of antisense oligonucleotides based on sulfonyl phosphoramidates in mdx mouse myotubes. Organic and Biomolecular Chemistry. 20(18), 3790-3797
[Journal article]Authored by: Filichev, V.
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Stanton, JAL., O'Brien, R., Hall, RJ., Chernyavtseva, A., Ha, HJ., Jelley, L., . . . Blaikie, R. (2022). Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains. Frontiers in Public Health. 9
[Journal article]Authored by: Filichev, V., Kurup, H.
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Su, Y., Bayarjargal, M., Hale, TK., & Filichev, VV. (2021). DNA with zwitterionic and negatively charged phosphate modifications: Formation of DNA triplexes, duplexes and cell uptake studies. Beilstein Journal of Organic Chemistry. 17, 749-761
[Journal article]Authored by: Filichev, V., Hale, T.
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Barzak, FM., Ryan, TM., Kvach, MV., Kurup, HM., Aihara, H., Harris, RS., . . . Jameson, GB. (2021). Small-angle x-ray scattering models of apobec3b catalytic domain in a complex with a single-stranded dna inhibitor. Viruses. 13(2)
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Su, Y., Edwards, PJB., Stetsenko, DA., & Filichev, VV. (2020). The Importance of Phosphates for DNA G-Quadruplex Formation: Evaluation of Zwitterionic G-Rich Oligodeoxynucleotides. ChemBioChem. 21(17), 2455-2466
[Journal article]Authored by: Edwards, P., Filichev, V.
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Roach, RJ., Garavís, M., González, C., Jameson, GB., Filichev, VV., & Hale, TK. (2020). Heterochromatin protein 1伪 interacts with parallel RNA and DNA G-quadruplexes. Nucleic Acids Research. 48(2), 682-693
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G.
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Kvach, MV., Barzak, FM., Harjes, S., Schares, HAM., Kurup, HM., Jones, KF., . . . Filichev, VV. (2020). Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2′-Deoxyzebularine Embedded in Single-Stranded DNA. ChemBioChem. 21(7), 1028-1035
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Barzak, FM., Harjes, S., Kvach, MV., Kurup, HM., Jameson, GB., Filichev, VV., . . . Harjes, E. (2019). Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2′-deoxyzebularine. Organic and Biomolecular Chemistry. 17(43), 9435-9441
[Journal article]Authored by: Filichev, V., Jameson, G., Kurup, H.
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Lepper, CP., Williams, MAK., Edwards, PJB., Filichev, VV., & Jameson, GB. (2019). Effects of Pressure and pH on the Physical Stability of an I-Motif DNA Structure. ChemPhysChem. 20(12), 1567-1571
[Journal article]Authored by: Edwards, P., Filichev, V., Jameson, G.
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Filitcheva, J., Edwards, PJB., Norris, GE., & Filichev, VV. (2019). 伪-2′-Deoxyguanosine can switch DNA G-quadruplex topologies from antiparallel to parallel. Organic and Biomolecular Chemistry. 17(16), 4031-4042
[Journal article]Authored by: Edwards, P., Filichev, V.
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Su, Y., Fujii, H., Burakova, EA., Chelobanov, BP., Fujii, M., Stetsenko, DA., . . . Filichev, VV. (2019). Neutral and Negatively Charged Phosphate Modifications Altering Thermal Stability, Kinetics of Formation and Monovalent Ion Dependence of DNA G-Quadruplexes. Chemistry - An Asian Journal. 14(8), 1212-1220
[Journal article]Authored by: Filichev, V.
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Kvach, MV., Barzak, FM., Harjes, S., Schares, HAM., Jameson, GB., Ayoub, AM., . . . Harjes, E. (2019). Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues. Biochemistry. 58(5), 391-400
[Journal article]Authored by: Filichev, V., Jameson, G.
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Shinkai, Y., Kashihara, S., Minematsu, G., Fujii, H., Naemura, M., Kotake, Y., . . . Fujii, M. (2017). Silencing of BCR/ABL Chimeric Gene in Human Chronic Myelogenous Leukemia Cell Line K562 by siRNA-Nuclear Export Signal Peptide Conjugates. Nucleic Acid Therapeutics. 27(3), 168-175
[Journal article]Authored by: Filichev, V.
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Harjes, S., Jameson, GB., Filichev, VV., Edwards, PJB., & Harjes, E. (2017). NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate. Nucleic Acids Research. 45(9), 5602-5613
[Journal article]Authored by: Edwards, P., Filichev, V., Jameson, G.
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Cree, SL., Fredericks, R., Miller, A., Pearce, FG., Filichev, V., Fee, C., . . . Kennedy, MA. (2016). DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. FEBS Letters. , 2870-2883
[Journal article]Authored by: Filichev, V.
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Cree, SL., Fredericks, R., Miller, A., Pearce, FG., Fee, C., Kennedy, MA., . . . Filichev, VV. (2016). DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. FEBS Letters. 590(17), 2870-2883
[Journal article]Authored by: Filichev, V.
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Le, BT., Filichev, VV., & Veedu, RN. (2016). Investigation of twisted intercalating nucleic acid (TINA)-modified antisense oligonucleotides for splice modulation by induced exon-skipping: In vitro. RSC Advances. 6(97), 95169-95172
[Journal article]Authored by: Filichev, V.
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Vasilyeva, SV., Filichev, VV., & Boutorine, AS. (2016). Application of Cu(I)-catalyzed azide-alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA. Beilstein Journal of Organic Chemistry. 12, 1348-1360
[Journal article]Authored by: Filichev, V.
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Mutsamwira, S., Ainscough, EW., Partridge, AC., Derrick, PJ., & Filichev, VV. (2016). G-Quadruplex Supramolecular Assemblies in Photochemical Upconversion. Chemistry - A European Journal. 22(30), 10376-10381
[Journal article]Authored by: Filichev, V.
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Suie, S., Raudsepp, A., Kent, LM., Keen, SAJ., Filichev, ., & Williams, MAK. (2015). DNA visualization in single molecule studies carried out with optical tweezers: Covalent versus non-covalent attachment of fluorophores. Biochemical and Biophysical Research Communications. 466(2), 226-231
[Journal article]Authored by: Filichev, V.
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Mutsamwira, S., Ainscough, EW., Partridge, AC., Derrick, PJ., & Filichev, VV. (2015). DNA-Based Assemblies for Photochemical Upconversion. Journal of Physical Chemistry B. 119(44), 14045-14052
[Journal article]Authored by: Filichev, V.
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Suei, S., Raudsepp, A., Kent, LM., Keen, SAJ., Filichev, VV., & Williams, MAK. (2015). DNA visualization in single molecule studies carried out with optical tweezers: Covalent versus non-covalent attachment of fluorophores. Biochemical and Biophysical Research Communications. 466(2), 226-231
[Journal article]Authored by: Filichev, V.
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Withers, JM., Telfer, SG., & Filichev, VV. (2015). Towards metal-mediated G-Quartet analogues: 1,2,4-Triazole nucleotides. Nucleosides, Nucleotides and Nucleic Acids. 34(4), 277-288
[Journal article]Authored by: Filichev, V.
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Doluca, O., Withers, JM., Loo, TS., Edwards, PJB., González, C., & Filichev, VV. (2015). Interdependence of pyrene interactions and tetramolecular G4-DNA assembly. Organic and Biomolecular Chemistry. 13(12), 3742-3748
[Journal article]Authored by: Edwards, P., Filichev, V.
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Doluca, O., Hale, TK., Edwards, PJB., González, C., & Filichev, VV. (2014). Assembly Dependent Fluorescence Enhancing Nucleic Acids in Sequence-Specific Detection of Double-Stranded DNA.. Chempluschem. 79(1), 2
[Journal article]Authored by: Edwards, P., Filichev, V., Hale, T.
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Stevens, AJ., Stuffrein-Roberts, S., Cree, SL., Gibb, A., Miller, AL., Doudney, K., . . . Kennedy, MA. (2014). G-Quadruplex structures and CpG methylation cause drop-out of the maternal allele in polymerase chain reaction amplification of the Imprinted MEST gene promoter. PLoS ONE. 9(12)
[Journal article]Authored by: Filichev, V.
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Mutsamwira, S., Ainscough, EW., Partridge, AC., Derrick, PJ., & Filichev, VV. (2014). DNA duplex as a scaffold for a ground state complex formation between a zinc cationic porphyrin and phenylethynylpyren-1-yl. Journal of Photochemistry and Photobiology A: Chemistry. 288, 76-81
[Journal article]Authored by: Filichev, V.
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Hale, TK., Norris, GE., Jameson, GB., & Filichev, VV. (2014). Helicases, G4-DNAs, and drug design. ChemMedChem. 9(9), 2031-2034
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G.
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Doluca, O., Hale, TK., Edwards, PJB., Gonzalez, C., & Filichev, VV. (2014). Assembly dependent fluorescence enhancing nucleic acids in sequence-specific detection of double-stranded DNA. ChemPlusChem. 79(1), 58-66
[Journal article]Authored by: Edwards, P., Filichev, V., Hale, T.
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Griffith, JA., Withers, JM., Martin, DJ., Rowlands, GJ., & Filichev, VV. (2013). Ligand assembly and chirality transfer guided by DNA modified with enantiomerically pure [2.2]paracyclophanes. RSC Advances. 3(24), 9373-9380
[Journal article]Authored by: Filichev, V.
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Doluca, O., Withers, JM., & Filichev, VV. (2013). Molecular engineering of guanine-rich sequences: Z-DNA, DNA triplexes, and G-quadruplexes. Chemical Reviews. 113(5), 3044-3083
[Journal article]Authored by: Filichev, V.
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Doluca, O., Boutorine, AS., & Filichev, VV. (2011). Triplex-forming twisted intercalating nucleic acids (TINAs): Design rules, stabilization of antiparallel DNA triplexes and inhibition of G-quartet-dependent self-association. ChemBioChem. 12(15), 2365-2374
[Journal article]Authored by: Filichev, V.
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Stephenson, AWI., Partridge, AC., & Filichev, VV. (2011). Synthesis of 尾-pyrrolic-modified porphyrins and their incorporation into DNA. Chemistry - A European Journal. 17(22), 6227-6238
[Journal article]Authored by: Filichev, V.
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Bomholt, N., Filichev, VV., & Pedersen, EB. (2011). Cationic modified nucleic acids for use in DNA hairpins and parallel triplexes. Organic and Biomolecular Chemistry. 9(12), 4527-4534
[Journal article]Authored by: Filichev, V.
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Pedersen, EB., Nielsen, JT., Nielsen, C., & Filichev, VV. (2011). Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids. Nucleic Acids Research. 39(6), 2470-2481
[Journal article]Authored by: Filichev, V.
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Stephenson, AWI., Bomholt, N., Partridge, AC., & Filichev, VV. (2010). Significantly enhanced DNA thermal stability resulting from porphyrin H-aggregate formation in the minor groove of the duplex. ChemBioChem. 11(13), 1833-1839
[Journal article]Authored by: Filichev, V.
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Filichev, VV. (2010). Recent advances in labelling of DNA with organic chromophores. Chemistry in New Zealand. 74(1), 24-31
[Journal article]Authored by: Filichev, V.
Cogoi, S., Paramasivam, M., Filichev, V., Géci, I., Pedersen, EB., & Xodo, LE. (2009). Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.. Journal of medicinal chemistry. 52(2), 564-568
[Journal article]Authored by: Filichev, V.
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Bomholt, N., Filichev, VV., & Pedersen, EB. (2009). The first postsynthetic 5′-5′ intercalators in triplex DNA - Solid-phase postsynthetic Sonogashira reaction and homocouplings on arylacetylenes. Helvetica Chimica Acta. 92(4), 716-730
[Journal article]Authored by: Filichev, V.
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Filichev, VV., & Pedersen, EB. (2009). DNA-conjugated organic chromophores in dna stacking interactions. Wiley Encyclopedia of Chemical Biology. 1, 493-524
[Journal article]Authored by: Filichev, V.
Filichev, VV., Astakhova, IV., Malakhov, AD., Korshun, VA., & Pedersen, EB. (2008). 1-, 2-, and 4-ethynylpyrenes in the structure of twisted intercalating nucleic acids: Structure, thermal stability, and fluorescence relationship. Chemistry - A European Journal. 14(32), 9968-9980
[Journal article]Authored by: Filichev, V.
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Cogoi, S., Paramasivam, M., Filichev, VV., Geci, I., Pedersen, EB., & Xodo, LE. (2008). Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene modified G4-decoys with antiproliferative activity in pancreatic cancer cells. Journal of Medicinal Chemistry. 52(2), 564-568
[Journal article]Authored by: Filichev, V.
Stephenson, AWI., Wagner, P., Partridge, AC., Jolley, KW., Filichev, VV., & Officer, DL. (2008). An alternative synthesis of 尾-pyrrolic acetylene-substituted porphyrins. Tetrahedron Letters. 49(39), 5632-5635
[Journal article]Authored by: Filichev, V.
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Paramasivam, M., Cogoi, S., Filichev, VV., Bomholt, N., Pedersen, EB., & Xodo, LE. (2008). Purine twisted-intercalating nucleic acids: A new class of anti-gene molecules resistant to potassium-induced aggregation. Nucleic Acids Research. 36(10), 3494-3507
[Journal article]Authored by: Filichev, V.
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Globisch, D., Bomholt, N., Filichev, VV., & Pedersen, EB. (2008). Stability of Hoogsteen-type triplexes - Electrostatic attraction between duplex backbone and Triplex-Forming Oligonucleotide (TFO) using an intercalating conjugate. Helvetica Chimica Acta. 91(5), 805-818
[Journal article]Authored by: Filichev, V.
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Van Daele, I., Bomholt, N., Filichev, VV., Van Calenbergh, S., & Pedersen, EB. (2008). Triplex formation by pyrene-labelled probes for nucleic acid detection fluorescence assays. ChemBioChem. 9(5), 791-801
[Journal article]Authored by: Filichev, V.
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Cogoi, S., Paramasivan, M., Xodo, LE., Filichev, VV., & Pedersen, EB. (2007). The effect of INA [(R)-1-O-(1-pyrenylmethyl)glycerol] insertions on the structure and biological activity of a G-quadruplex from a critical KRAS G-rich sequence. Nucleosides, Nucleotides and Nucleic Acids. 26(10-12), 1641-1643
[Journal article]Authored by: Filichev, V.
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Géci, I., Filichev, VV., & Pedersen, EB. (2007). Stabilization of parallel triplexes by Twisted Intercalating Nucleic Acids (TINAs) incorporating 1,2,3-triazole units and prepared by microwave-accelerated click chemistry. Chemistry - A European Journal. 13(22), 6379-6386
[Journal article]Authored by: Filichev, V.
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Gécí, I., Filichev, VV., & Pedersen, EB. (2006). Synthesis of twisted intercalating nucleic acids possessing acridine derivatives, thermal stability studies. Bioconjugate Chemistry. 17(4), 950-957
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Gaber, H., Olsen, TR., Jørgensen, PT., Jessen, CH., & Pedersen, EB. (2006). Twisted intercalating nucleic acids - Intercalator influence on parallel triplex stabilities. European Journal of Organic Chemistry. (17), 3960-3968
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Nielsen, MC., Bomholt, N., Jessen, CH., & Pedersen, EB. (2006). High thermal stability of 5′-5′-linked alternate Hoogsteen triplexes at physiological pH. Angewandte Chemie - International Edition. 45(32), 5311-5315
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Vester, B., Hansen, LH., & Pedersen, EB. (2005). Easily denaturing nucleic acids derived from intercalating nucleic acids: Thermal stability studies, dual duplex invasion and inhibition of transcription start. Nucleic Acids Research. 33(22), 7129-7137
[Journal article]Authored by: Filichev, V.
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Filichev, VV., & Pedersen, EB. (2005). Stable and selective formation of Hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) prepared via postsynthetic sonogashira solid-phase coupling reactions. Journal of the American Chemical Society. 127(42), 14849-14858
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Vester, B., Hansen, LH., Abdel Aal, MT., Babu, BR., Wengel, J., . . . Pedersen, EB. (2005). Enhanced inhibition of transcription start by targeting with 2′-OMe pentaribonucleotides comprising locked nucleic acids and intercalating nucleic acids. ChemBioChem. 6(7), 1181-1184
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Christensen, UB., Pedersen, EB., Babu, BR., & Wengel, J. (2004). Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: Thermal stability studies. ChemBioChem. 5(12), 1673-1679
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Hilmy, KMH., Christensen, UB., & Pedersen, EB. (2004). Intercalating nucleic acids: The inversion of the stereocenter in 1-O-(pyren-1-ylmethyl)glycerol from R to S. Thermal stability towards ssDNA, ssRNA and its own type of oligodeoxynucleotides. Tetrahedron Letters. 45(25), 4907-4910
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Vester, B., & Pedersen, EB. (2004). Hexofuranosyl thymidines inserted into oligodeoxynucleotides via their two exocyclic hydroxy groups. Oligo synthesis and RNase H activity. Bioorganic and Medicinal Chemistry. 12(11), 2843-2851
[Journal article]Authored by: Filichev, V.
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Christensen, UB., Wamberg, M., El-Essawy, FAG., Ismail, AEH., Nielsen, CB., Filichev, VV., . . . Pedersen, EB. (2004). Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities. Nucleosides, Nucleotides and Nucleic Acids. 23(1-2), 207-225
[Journal article]Authored by: Filichev, V.
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Filichev, VV., & Pedersen, EB. (2004). Synthesis and incorporation of an 伪-hexofuranosyl thymidine into oligodeoxynucleotides via its two exocyclic OH-groups. Bioorganic and Medicinal Chemistry Letters. 14(3), 581-584
[Journal article]Authored by: Filichev, V.
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Filichev, VV., & Pedersen, EB. (2003). Intercalating nucleic acids (INAs) with insertion of N-(pyren-1-ylmethyl)-(3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. DNA (RNA) duplex and DNA three-way junction stabilities. Organic and Biomolecular Chemistry. 1(1), 100-103
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Malin, AA., Ostrovskii, VA., & Pedersen, EB. (2002). Synthesis of a thymidine dimer containing a tetrazole-2,5-diyl internucleosidic linkage and its insertion into oligodeoxynucleotides. Helvetica Chimica Acta. 85(9), 2847-2855
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Jasko, MV., Malin, AA., Zubarev, VY., & Ostrovskii, VA. (2002). Synthesis of novel thymidine derivatives containing a polycyclic tetrazole linker. Tetrahedron Letters. 43(10), 1901-1903
[Journal article]Authored by: Filichev, V.
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Filichev, VV., & Pedersen, EB. (2001). Synthesis of 1′-aza-C-nucleosides from (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. Tetrahedron. 57(44), 9163-9168
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Brandt, M., & Pedersen, EB. (2001). Synthesis of an aza analogue of 2-deoxy-D-ribofuranose and its homologues. Carbohydrate Research. 333(2), 115-122
[Journal article]Authored by: Filichev, V.
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Zubarev, VY., Trifonov, RE., Filichev, VV., Ostrovskii, VA., Abell, AD., & Edmonds, MK. (2001). Synthesis, X-ray and conformational studies of novel tetrazole-containing macrocycles: 4,13-dioxa-1,7,8,9,17,18,19,20-octaazatricyclo[14.2.1.1(7,10)]icosa-8,10(20),16(19),17-tetraene and 4,14-dioxa-1,7,8,9,10,18,19,20-octaazatricyclo[15.2.1.0(7,10)]icosa-8,10,17(20),18-tetraene. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2. (3), 417-421
[Journal article]Authored by: Filichev, V.
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Zubarev, VY., Filichev, VV., Trifonov, RE., & Ostrovskii, VA. (1999). 1,5-Di(tetrazol-5-yl)-3-oxapentane as a substrate in the synthesis of novel heterocyclic systems. Mendeleev Communications. 9(3), 116-117
[Journal article]Authored by: Filichev, V.
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Zubarev, VY., Filichev, VV., Trifonov, RE., & Ostrovskii, VA. (1999). 1,5-Di(tetrazol-5-yl)-3-oxapentane as a substrate in the synthesis of novel heterocyclic systems. MENDELEEV COMMUNICATIONS. (3), 116-117
[Journal article]Authored by: Filichev, V.
3
Filichev, VV., Malin, AA., Yas'ko, MV., Shcherbinin, MB., & Ostrovskii, VA. (1998). Synthesis of 2′,3′-Dideoxy-3′-[5-(4-fluorophenyl)-2-tetrazolyl]thymidine. Russian Journal of Organic Chemistry. 34(3), 449-451
[Journal article]Authored by: Filichev, V.
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Filichev, VV., Malin, AA., Yasko, MV., Shcherbinin, MB., & Ostrovskii, VA. (1998). Synthesis of 3 '-[5-(4-fluorophenyl)tetrazol-2-yl]-2 ',3 '-didehydroxythymidine. ZHURNAL ORGANICHESKOI KHIMII. 34(3), 477-479
[Journal article]Authored by: Filichev, V.
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IP

Kurup, H., Filichev, VV., Harjes, E., Harjes, S., Jameson, G., Kvach, M., . . . Su, Y.(2022). . WO2022162536: SINGLE STRANDED DNA ENZYME INHIBITORS
[Patent]Authored by: Filichev, V., Jameson, G., Kurup, H.Contributed to by: Kurup, H.
Read Abstract: abstract icon
Doluca, O., Hale, TK., & Filichev, VV.(2013). . 609844: Assembly-dependent Fluorescence Enhancing Nucleic Acids (AFENA) in Sequence-specific Detection of Nucleic Acids in Fluorescence Assay.
[Patent]Authored by: Filichev, V., Hale, T.
Filichev, VV., & Pedersen, EB.(2011). . 564146: New Zealand, published and granted: Stable and selective formation of Hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of TINA.
[Patent]Authored by: Filichev, V.
Pedersen, EB., Van Daele, I., Filichev, VV., & Bomholt, N.(2008). . WO2008067825: World Intellectual Property Office, published application: Hoogsteen-type triplex formation of pyrene labelled probes for nucleic acid detection in fluorescence assay
[Patent]Authored by: Filichev, V.
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Filichev, VV., & Pedersen, EB.(2006). . WO2006125447: World Intellectual Property Office, published application: Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalatin nucleic acids (tina) and process for the preparation of tina
[Patent]Authored by: Filichev, V.
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Filichev, VV., & Pedersen, EB.. 20090216003: United States of America, published application: Stable and selective formation of Hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of TINA
[Patent]Authored by: Filichev, V.
Filichev, VV., & Pedersen, EB.. 2006753367: Europen Patent Office, published application: Stable and selective formation of Hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of TINA
[Patent]Authored by: Filichev, V.
Filichev, VV., & Pedersen, EB.. 2006251496: Australia, published application: Stable and selective formation of Hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of TINA
[Patent]Authored by: Filichev, V.
Filichev, VV., Pedersen, EB., Van Daele, I., & Bomholt, N.. 2007846444: Europen Patent Office, published application: Hoogsteen-type triplex formation of pyrene labelled probes for nucleic acid detection in fluorescence assay
[Patent]Authored by: Filichev, V.

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Conference

Filichev, V., Jameson, G., Elena, H., & Hale, T. (2023, September). Inhibition of innate-immunity enzymes that are hijacked by cancer cells to evolve therapeutic resistance. Presented at New Zealand Society of Oncology. Napier.
[Conference Oral Presentation]Authored by: Filichev, V., Hale, T., Jameson, G.
Bao, LT., Herdewijn, P., Filichev, VV., Wilton, SD., Fletcher, S., & Veedu, RN.EXPLORING NOVEL THERAPEUTIC CHEMISTRIES IN EXON-SKIPPING FOR DUCHENNE MUSCULAR DYSTROPHY. JOURNAL OF GENE MEDICINE. 20 (1)1099-498X.
[Conference]Authored by: Filichev, V.
Filichev, VV., Harjes, S., Barzak, F., Kvach, MV., Jameson, GB., & Harris, RS. (2017). Modulating APOBEC deaminase activity with ssDNA containing zebularine. , 7th Cambridge Symposium on Nucleic Acids Chemistry and Biology
[Conference Abstract]Authored by: Filichev, V., Jameson, G.
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Harjes, E., Harjes, S., Filichev, V., Jameson, GB., & Edwards, P.(2016, October). How DNA mutating enzymes interact with their DNA substrates. .
[Conference]Authored by: Edwards, P., Filichev, V., Jameson, G.
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Filichev, VV.(2011, June 28). G-rich sequences and intercalating nucleic acids: G-quadruplexes versus antiparallel triplexes. (pp. OP22). , Third International Meeting on G-Quadruplex and G-assembly
[Conference Abstract]Authored by: Filichev, V.

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Filichev, VV., Withers, JM., & Telfer, SG.(2011, June 28). Metal-ion-mediated quartets in G-quadruplexes. (pp. P85). , Third International Meeting on G-Quadruplex and G-assembly
[Conference Abstract]Authored by: Filichev, V.
Filichev, VV., Withers, JM., & Telfer, SG. (2011). Metal-ion-mediated quartets in G-quadruplexes. Poster session presented at the meeting of Third International Meeting on G-Quadruplex and G-assembly. Sorrento, Italy
[Conference Poster]Authored by: Filichev, V.
Filichev, VV. (2011, June). G-rich sequences and intercalating nucleic acids: G-quadruplexes versus antiparallel triplexes. Presented at Third International Meeting on G-Quadruplex and G-assembly. Sorrento, Italy.
[Conference Oral Presentation]Authored by: Filichev, V.
Filichev, VV. (2011, June). Synthesis of 尾-pyrrolic modified porphyrins and their incorporation into DNA. Presented at 3rd NAC Mini-Symposium - Nucleic Acid Chemical Biology anno 2011. University of Southern Denmark, Odense, Denmark.
[Conference Oral Presentation]Authored by: Filichev, V.
Boutorine, A., Doluca, O., & Filichev, V. (2010). Optimization of the twisted intercalating nucleic acids forming triple helix with DNA and their conjugation to MGB. In XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids, IRT 2010(pp. 597 - 598). : University of Lyon
[Conference Abstract]Authored by: Filichev, V.
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Stephenson, A., Bomholt, N., Partridge, A., & Filichev, V. (2010). Assembly of porphyrins in the minor groove of DNA duplexes. In XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids, IRT 2010(pp. 560 - 561). : University of Lyon
[Conference Abstract]Authored by: Filichev, V.
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Boutorine, AS., Doluca, O., & Filichev, VV. (2009). Optimization of the sequence of twisted intercalating nucleic acids (TINA) forming triple helix with the polypurine tract of the proviral HIV DNA.. Nucleic acids symposium series (2004). (pp. 139 - 140).
[Conference Paper in Published Proceedings]Authored by: Filichev, V.
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6
Stephenson, AW., Filichev, VV., & Partridge, A. (2009). DNA scaffolded porphyrins for light harvesting applications. Poster session presented at the meeting of AMN4 Conference. Dunedin, NZ
[Conference Poster]Authored by: Filichev, V.
Stephenson, AW., Filichev, VV., & Partridge, A. (2008). DNA scaffolded porphyrins for light harvesting applications. Poster session presented at the meeting of AMN-4: Conference on Advanced Materials and Nanotechnology. Victoria University, Wellington, NZ
[Conference Poster]Authored by: Filichev, V.
Stephenson, AW., Filichev, VV., & Partridge, A. (2008). DNA scaffolded porphyrins for light harvesting applications. In AMN4 Advanced Materials and Nanotechnology Conference: The MacDiamid Institute for Advanced Materials and Nanotechnology.
[Conference Abstract]Authored by: Filichev, V.
Pedersen, EB., Osman, AMA., Globisch, D., Paramasivam, M., Cogoi, S., Bomholt, N., . . . Filichev, VV. (2008). Triplex glue by synthesizing conjugated flexible intercalators. Nucleic acids symposium series (2004). (pp. 37 - 38).
[Conference Paper in Published Proceedings]Authored by: Filichev, V.
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2
Filichev, VV., Astakhova, IV., Malakhov, AD., Korshun, VA., & Pedersen, EB. (2008). DNA glue: 1-, 2- and 4-ethynylpyrenes in the structure of twisted intercalating nucleic acids (TINAs), DNA duplexes/triplexes and interstrand excimer formation. Nucleic acids symposium series (2004). (pp. 347 - 348).
[Conference Paper in Published Proceedings]Authored by: Filichev, V.
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4
Bauerfeind, LH., & Filichev, VV. (2008). Synthesis of novel fluorescent DNA monomer for incorporation into triplex forming oligonucleotides for sequence specific nucleic acid detection. Poster session presented at the meeting of Chemistry and the Biosphere Conference. Dunedin, NZ
[Conference Poster]Authored by: Filichev, V.
Filichev, VV. (2008). 1-, 2-, and 4-ethynylpyrenes in the structure of twisted intercalating nucleic acids. Poster session presented at the meeting of Chemistry and the Biosphere Conference. Dunedin, NZ
[Conference Poster]Authored by: Filichev, V.
Withers, JM., Rowlands, GJ., & Filichev, VV. (2008). Fluorescent nucleotides utilizing [2,2]para-cyclophane for the detection of codon mismatches. Poster session presented at the meeting of Chemistry and the Biosphere Conference. Dunedin, NZ
[Conference Poster]Authored by: Filichev, V.
Filichev, VV., & Pedersen, EB. (2007). DNA glue: Intercalating nucleic acids and DNA duplexes/triplexes. In International Symposium on Advances in Synthetic and Medicinal Chemistry(pp. 178). : LD Organisation
[Conference Abstract]Authored by: Filichev, V.
Schmitt, E., Muller, P., Paramavisam, M., Filichev, VV., Bomholt, N., Schwarz Finsterle, J., . . . Hausmann, M. (2007). Integrative design of selectively colocalizing oligonucleotide probes. Poster session presented at the meeting of Integrative Bioinformatics International Workshop 2007. University of Ghent, Belgium
[Conference Poster]Authored by: Filichev, V.
Filichev, VV. (2007). DNA glue: Intercalating nucleic acids and DNA duplexes/triplexes. Poster session presented at the meeting of International Symposium on Advances in Synthetic and Medicinal Chemistry. St Petersburg, Russia
[Conference Poster]Authored by: Filichev, V.
Pedersen, EB., Filichev, VV., Nielsen, MC., Bomholt, N., Jessen, CH., & Geci, I. (2006). Conjugation of flexible intercalators for triplex stabilization and for alternate strand triplex connectivity. Poster session presented at the meeting of 17th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. Bern, Switzerland
[Conference Poster]Authored by: Filichev, V.
Filichev, VV. (2006, December). DNA glue: Flexible intercalating systems and DNA triplexes. Presented at Back to the Basics: From Small Molecules to Materials and Surfaces: New Zealand Institute of Chemistry (NZIC) 2006 Conference. Rotorua, NZ.
[Conference Oral Presentation]Authored by: Filichev, V.
Filichev, VV. (2006). DNA glue: Flexible intercalating systems and DNA triplexes. In Back to the Basics: From Small Molecules to Materials and Surfaces: Proceedings of the New Zealand Institute of Chemistry (NZIC) 2006 Conference(pp. 55). : New Zealand Institute of Chemistry
[Conference Abstract]Authored by: Filichev, V.
Geci, I., Filichev, VV., & Pedersen, EB.(2005, September). Synthesis of twisted intercalating nucleic acids (TINA) possesing acridine derivatives. Chemistry of Nucleic Acid Components. (pp. 401 - 402).
[Conference]Authored by: Filichev, V.

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Other

Filichev, VV. (2009). DNA glue: Intercalating nucelic acids and dsdna targeting. Presented at St Ptersburg State Technological Institute (Technical University), St Petersburg, Russia.
[Oral Presentation]Authored by: Filichev, V.
Filichev, VV. (2009). DNA glue: Intercalating nucleic acids and dsdna targeting. Presented at Kirchhoff Institute of Physics, Heidelberg University.
[Oral Presentation]Authored by: Filichev, V.
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Filichev, VV. (2008). DNA Glue: Intercalating nucleic acids and dsDNA targeting. Presented at Palmerston North, New Zealand.
[Oral Presentation]Authored by: Filichev, V.
Filichev, VV. (2007). Intercalating nucleic acids and dsDNA targeting: Strand invasion, inhibition of transcription, triplex formation. Presented at Victoria University of Wellington, NZ.
[Oral Presentation]Authored by: Filichev, V.
Filichev, VV. (2007). DNA glue: Intercalating nucleic acids and dsDNA targeting. Presented at University of Southern Denmark, Odense, Denmark.
[Oral Presentation]Authored by: Filichev, V.

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Filichev, VV. (2007). Intercalating nucleic acids and dsDNA targeting: Strand invasion, inhibition of transcription, triplex formation. Presented at 羞羞视频, Palmerston North, NZ.
[Oral Presentation]Authored by: Filichev, V.
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Consultancy and Languages

Languages

  • Danish
    Spoken ability: Average
    Written ability: Average
  • Russian
    Spoken ability: Excellent
    Written ability: Excellent

Teaching and Supervision

Contact Supervisor

Summary of Doctoral Supervision

Position Current Completed
Main Supervisor 1 4
Co-supervisor 2 2

Current Doctoral Supervision

Main Supervisor of:

  • Thakshila Dayananda - Doctor of Philosophy
    Investigation of Structural and Biophysical Aspects of DNA Aptamers in Binding to Complex Illicit Drugs and Utilisation of Aptamers in Biosensing Platform Development for Health and Environmental Monitoring

Co-supervisor of:

  • Dong Luo - Doctor of Philosophy
    Structural basis of A3G-DNA interaction for antiviral defense
  • Aseel Mohammad - Doctor of Philosophy
    Investigating the Role of G-Quadruplexes in Oncogene Silencing

Completed Doctoral Supervision

Main Supervisor of:

  • 2023 - Bruce Chilton - Doctor of Philosophy
    Studies Towards Thermodynamically Stable G-Quadruplexes Embedded in Canonical DNA Duplexes
  • 2021 - ~ Harikrishnan Mohana Kurup - Doctor of Philosophy
    Design, Synthesis, and Evaluation of Cross-linked Single-stranded DNAs as Inhibitors of APOBEC3 Enzymes
  • 2021 - Yongdong Su - Doctor of Philosophy
    Targeting DNA Secondary Structures Using Chemically Modified Oligonucleotides
  • 2020 - Fareeda Barzak - Doctor of Philosophy
    Biophysical and biochemical characterisation of DNA-based inhibitors of the cytosine-mutating APOBEC3 enzymes

Co-supervisor of:

  • 2023 - Ruby Roach - Doctor of Philosophy
    Untangling the interaction between HP1伪 and the TERRA G-quadruplex
  • 2019 - Heather Jameson - Doctor of Philosophy
    Interior Decoration of Metal-Organic Frameworks through a Thermolabile Protecting Group Strategy